Objectives: To survey the burden of the main caregivers of total hip replacement (THR) postoperative patients and to discuss the related influence factors. Methods: The self-designed general condition questionnaire targeting patients and caregivers, patients’ self-nursing scale (ADL), psychological capital scale, social support revalued scale (SRSS) and caregiver burden inventory (CBI) were adopted for 120 THR patients in our hospital and their caregivers. Results: The CBI score of the main caregivers of THR patients was 45.82±12.77; this score indicated health risk burden. The CBI score of the patients was negatively correlated with social support score, objective support and its availability score, psychological capital score and gratitude & dedication dimension score (P<0.05). As indicated by the multiple regression analysis results, the influence factors of caregivers’ burden were as follows: patients’ self-care ability, caregivers’ age, family per-capita monthly income, caring time, gratitude & dedication, objective support and its availability (P<0.001). They together could explain 61.8% of the variance variation amount. Conclusion: The caregivers of THR patients have obvious care burden. Therefore, the clinical medical staff should work out targeted intervention scheme considering the personality characteristics of the patients and caregivers and mobilize the social support force to lighten the caregivers’ care burden.