Objective: To explore the effect of different proportions of blood transfusion in the treatment of patients with traumatic massive hemorrhage. Methods: The data of 97 patients with traumatic massive hemorrhage treated in Chizhou People’s Hospital from January 2016 to July 2021 were retrospectively analyzed. According to the different proportions of fresh frozen plasma (FFP): red blood cells suspension (RBCs), they were divided into group A (≤1:2, n=28), group B (>1:2–1:1, n=35) and group C (>1:1, n=34). The dosage of blood products, coagulation function and prognosis of the three groups were compared and analyzed. Results: Compared with before blood transfusion, PT, APTT and INR in group A were significantly prolonged. There were no significant changes in PT, APTT and INR before and after blood transfusion in group B and group C (P>0.05). PT, APTT and INR after blood transfusion in group A were higher than those in group B and group C (P<0.05), but there was no significant difference in PT, APTT and INR between group B and group C (P>0.05). The amount of FFP infusion in group A, group B and group C during hospitalization increased significantly in turn (P<0.05), and the difference between the two groups was statistically significant (P<0.05). There was no significant difference in hospital stay, ICU stay, 24 h and 30 d mortality among the three groups (P>0.05). Conclusion: It is recommended that FFP: RBCs 1:2–1:1 blood transfusion be used to treat patients with traumatic massive hemorrhage, which can reduce coagulation dysfunction and save blood products without affecting the treatment effect.