文章摘要

肺癌的气腔内播散

作者: 1,2徐跻京, 1丁瀚林, 3黄兴, 1蒋峰
1 南京医科大学附属肿瘤医院，江苏省肿瘤医院，江苏省肿瘤防治研究所，江苏省肿瘤医院胸外科，南京 210009
2 泰州市中医院胸外科，江苏 泰州 225500
3 南京医科大学附属肿瘤医院，江苏省肿瘤医院，江苏省肿瘤防治研究所，江苏省肿瘤医院病理科，南京 210009
通讯: 蒋峰 Email: fengjiang_nj@njmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2022.07.037
基金: 国家自然科学基金(81672294)。

摘要

2015年，世界卫生组织将肿瘤气腔内播散(spread through air space，STAS)定义为肺腺癌的一种独特的侵袭模式。随后，大量研究报道了其与肺腺癌局部复发及较差预后的相关性。在肺鳞癌、非典型类癌及神经内分泌肺癌等肺癌癌种中亦陆续出现了STAS相关的报道。随着对STAS理解的逐步深入，STAS在肺癌的临床治疗决策制订中的潜在价值也逐渐被发现，但现阶段临床研究者对于STAS发生、发展的机制不明确，缺乏统一定量方法，针对STAS的临床诊疗共识也尚未形成，STAS的临床价值亟待进一步挖掘。现对STAS在肺癌领域中已有的研究进行分析，阐述STAS与患者预后间的联系，梳理STAS的临床判读、定量方法、形成的分子机制，并对该领域的热点问题及发展方向进行展望。
关键词： 肺癌；气腔内播散；病理分型

Spread through air space in lung cancer

Authors: 1,2XU Jijing, 1DING Hanlin, 3HUANG Xing, 1JIANG Feng
1 Department of Thoracic Surgery, Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Jiangsu Cancer Hospital, Nanjing 210009, China
2 Department of Thoracic Surgery, Taizhou Traditional Chinese Medicine Hospital, Taizhou Jiangsu 225500, China
3 Department of Pathology, Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Jiangsu Cancer Hospital, Nanjing 210009, China

CorrespondingAuthor: JIANG Feng Email: fengjiang_nj@njmu.edu.cn

DOI: 10.3978/j.issn.2095-6959.2022.07.037

Foundation: This work was supported by the National Natural Science Foundation of China (81672294).

Abstract

In 2015, the tumor spread through air space (STAS) was defined by the world Health Organization (WHO) as a unique invasion pattern of lung adenocarcinoma. Subsequently, a large number of studies about STAS have reported its association with local recurrence and poor prognosis in lung adenocarcinoma. The presence of STAS has also been reported in squamous carcinoma, atypical carcinoid, neuroendocrine lung cancer and non-small cell lung cancer. With the deepening of the understanding of STAS, the potential value of STAS in clinical treatment decision-making has been gradually discovered. However, the occurrence and development mechanism of STAS are still unclear, and there is no standard quantitative method. In the clinical diagnosis and treatment procedure, a consensus has not been reached and the clinical importance of STAS needs to be further explored. This paper analyzed the existing studies on STAS in the field of lung cancer, elaborated the relationship between STAS and patient prognosis, and summarized the clinical interpretation, quantitative methods, and molecular mechanism of STAS in order to prospect the hot issues and development direction in this field.

Keywords： lung cancer; spread through air space; pathological subtype

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