Objective: To explore the characteristics of clinicopathology, so as to reduce misdiagnosis rate. Methods: A case of breast non-hodgkin’s lymphoma in Affiliated Hospital of Academy of Military Medical Sciences clinicopathology data was retrospectively analyzed. Results: The patient was admitted for bilateral breast neoplasm for one month and mass did not change significantly after anti-inflammatory treatment, so as to initially consider “breast cancer”. The patient was found that it was visible placeholder among abdominal pelvic, right kidney, right iliac muscle and the left anal mention muscle by PET-CT and the abdominal CT, except bilateral breast high metabolism neoplasm. Pathological biopsy results began to consider breast poorly differentiated carcinoma with multiple transfer, and confirmed that breast non-hodgkin’s T cell lymphoma by immunohistochemistry, and the type was ALK negative anaplastic large cell lymphoma. Conclusion: Clinical and pathological type of breast non-Hodgkin’s lymphoma was rare, which can be misdiagnosed poorly differentiated carcinoma, easily, so as to strengthen the clinical and pathological characteristics of breast lymphoma awareness and careful analysis of the condition in order to avoid or reduce misdiagnosis.