Objective: To explore the clinicopathological characteristics of intestinal lymphoid polyposis in adults. Methods: The histopathological features and immunophenotype of four cases of adult intestinal lymphoid polyposis were studied, relevant literatures were reviewed. Results: A total of 3 males and 1 female were studied, aged 75, 75, 46 and 70, respectively. In all four cases, identification of the polyposis was incidental during the examination of resected of terminal ileum and ileocecal region due to other diseases. Gross findings were multiple polyps in the terminal ileum, measuring 0.1~0.5 cm in diameter. Microscopically, hyperplasia of mucosa-associated lymphoid tissue was noticed. The polyps were composed of closely aggregated lymphoid follicles. The follicles contained prominent germinal centers surrounded by a mantle of small lymphocytes. Immunohistochemical staining showed the follicles to be composed of CD20 (+) and Clyclin D1 (−) lymphocytes. Cells in germinal center did not express Bcl-2. Conclusion: Lymphoid polyposis is a rare benign tumor featuring unique clinicopathological characteristics. And the diagnosis relies on histopathological analysis and some ancillary markers.