Slit-Robo信号通路作用的研究进展
| 作者: |
1李霖,
1卿国忠
1 南华大学附属第一医院急诊科,湖南 衡阳421001 |
| 通讯: |
卿国忠
Email: gzqing9923@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2013.01.013 |
| 基金: | 湖南省科技厅应用基础研究计划(2011FJ3170) |
摘要
分泌型糖蛋白Slit及其受体Robo最初作为一类重要的神经元轴突导向因子被发现。随着对Slit-Robo信号通路作用机制研究的不断深入,该信号通路还参与血管新生、肿瘤血管发生、炎症、白细胞趋化及血管渗漏等过程。
关键词：
脓毒症
Slit-Robo信号通路
神经轴突导向
内皮渗漏
Advance in research on the function of Slit-Robo pathway
CorrespondingAuthor: QING Guozhong Email: gzqing9923@163.com
DOI: 10.3978/j.issn.2095-6959.2013.01.013
Abstract
As secreted proteins, Slit as well as its receptor roundabout(Robo) initially is considered as axon guidance cues. With the development of research, it has been shown that Slit-Robo signal pathway is involved in mediating angiogenesis, tumor angiogenesis, inflammation, leukocyte chemotaxis, and vascular leakage, etc.