Objective: To determine the clinicopathologic feature, immunohistochemistry, diagnosis and differential diagnosis of gastric schwannoma. Methods: Clinical characteristics, pathological morphology and immunohistochemical staining in 8 cases of gastric schwannoma were analyzed, and literature was reviewed. Results: The patients included 5 females and 3 males. The age of patients ranged from 30 to 81 years (median=61 years). The size of the tumors ranged from 1.0 to 7.0 cm in diameter (median=3.0 cm). Gross examination showed that gastric schwannoma was white and without true fibrous capsule. The tumors were composed entirely or mainly of short spindle shaped cells which were described in a palisade manner or in bundles. All tumors showed a lymphocytic cuffing at the peripheral part. Immunohistochemistry results showed, the expression of S-100 was all positive, and glial fibrillary acidic protein (GFAP) was positive in 7 cases while CD117, CD34, Dog1, a-Smooth muscle actin (a-SMA) and Desmin were negative. Three cases showed positivity for PDGFR, but with no mutations found in c-kit and platelet-derived growth factor receptor α (PDGFRα). Conclusion: Gastric schwannoma is a benign tumor and should be differentially diagnosed from the gastrointestinal stromal tumor.