舒芬太尼靶控输注的临床应用进展
| 作者: |
1丁慧萍,
1宦烨,
1王雯,
1蔡宏伟
1 中南大学湘雅医院麻醉科，长沙 410000 |
| 通讯: |
蔡宏伟
Email: chw2005@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.04.035 |
| 基金: | 湖南省科技厅重点研发计划项目(2017SK2034)；中南大学湘雅医院麻醉科科研项目(3302012014002)。 |
摘要
靶控输注(target-controlled Infusion，TCI)是在输注静脉麻醉药物时应用药代动力学和药效动力学 原理，通过调节目标(血浆或效应室)的药物浓度来控制或维持麻醉深度。舒芬太尼TCI广泛应用于 不同手术的麻醉，本文将主要介绍舒芬太尼TCI在全麻的诱导和气管插管、心脏手术、需要术中唤 醒手术、病态肥胖患者手术以及术后镇痛中的应用，旨在为今后的临床应用和基础研究提供理论 参考。
关键词：
舒芬太尼；靶控输注；麻醉
Clinical application progress of sufentanil target-controlled infusion
CorrespondingAuthor: CAI Hongwei Email: chw2005@163.com
DOI: 10.3978/j.issn.2095-6959.2022.04.035
Foundation: This work was supported by the Key R&D Project of Hunan Provincial Department of Science and Technology (2017SK2034) and the Scientific Research Project of Department of Anesthesiology, Xiangya Hospital of Central South University (3302012014002), China.
Abstract
Target-controlled Infusion (TCI) is the application of pharmacokinetics and pharmacodynamic principles when intravenous anesthetics are infused, and the depth of anesthesia is controlled or maintained by adjusting the drug concentration of the target (plasma or effect chamber). Sufentanil TCI is widely used in anesthesia for different operations. This article summarizes domestic and foreign literature, to give an introduction of sufentanil TCI in induction of general anesthesia and tracheal intubation, cardiac surgery, surgery that requires intraoperative wake- up, surgery for morbidly obese patients and the application of postoperative analgesia, with an aim to provide theoretical references for future clinical applications and basic research.
Keywords：
sufentanil; target-controlled infusion; anesthesia