线粒体活性氧的产生及影响因素探讨
| 作者: |
1田留洋,
2刘昱圻,
2李泱
1 南开大学医学院，天津 300071 2 解放军总医院心内科，北京 100853 |
| 通讯: |
刘昱圻
Email: ametuofo980869@163.com 李泱 Email: liyangbsh@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.09.021 |
| 基金: | 国家自然科学基金项目, 81470542/H0214 |
摘要
线粒体是重要的真核细胞的细胞器，通过氧化磷酸化为细胞提供90%以上能量。线粒体功能紊乱与氧化磷酸化功能损害和活性氧产生增多密切相关，是导致多种疾病的重要的病理基础。本文将针对线粒体产生活性氧的方式、影响因素以及活性氧对机体组织及细胞的影响进行阐述。
关键词：
线粒体
氧化磷酸化
活性氧
活性氧的影响
Reactive oxidative species caused by mitochondrion and relative factors
CorrespondingAuthor: LIU Yuqi Email: ametuofo980869@163.com
DOI: 10.3978/j.issn.2095-6959.2015.09.021
Abstract
Mitochondrionisan eukaryotic organelle that generatesmore than 90% of the energy in the cell by oxidative phosphorylation (OXPHOS). Mitochondrial dysfunction is an important pathophysiological mechanism for many common disorders, associated with impairing of OXPHOS and increasing reactive oxidative species (ROS) production. In this review we will discuss production of ROS caused by mitochondrion, affected factors and multiple effects on the tissue and cells.