Objective: To explore the application effects of sevoflurane combined with remifentanil in children with indirect inguinal hernia undergoing laparoscopic high ligation of hernia sac. Methods: A total of 80 children with indirect inguinal hernia who needed laparoscopic high ligation of hernia sac and were admitted to the hospital were enrolled between October 2019 and October 2020. They were divided into an observation group (n=40) and a control group (n=40) according to random number table method. The observation group was given sevoflurane combined with remifentanil for anesthesia, whereas control group underwent routine anesthesia. The scores of Children’s Hospital of Eastern Ontario Pain Scale (CHEOPS) and Pediatric Anesthesia Emergence Delirium (PAED), heart rate (HR) and mean arterial pressure (MAP) at different time points, and incidence of adverse reactions in the two groups were observed. Results: CHEOPS scores in observation group were significantly lower than those in control group at 30 min, 2 h, 6 h, 12 h and 24 h after surgery (P<0.05). The difference in PAED scores between the two groups was not statistically significant immediately after entering PACU, at 10, 20 and 30 min after surgery (P>0.05). At T₁, T₂ and T₃, HR and MAP levels in observation group were significantly lower than those in control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The application of sevoflurane combined with remifentanil can effectively relieve pain and maintain the stability of vital signs in children with indirect inguinal hernia undergoing laparoscopic high ligation of hernia sac, with high safety.