2例肾平滑肌肿瘤临床病理分析
| 作者: |
1,2吴梅,
3王铮,
1,2刘慧
1 徐州医科大学病理学教研室，江苏 徐州 221000 2 徐州医科大学附属医院病理科，江苏 徐州 221000 3 徐州医科大学附属医院神经外科，江苏 徐州 221000 |
| 通讯: |
刘慧
Email: hliu@xzhmu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2022.03.038 |
| 基金: | 徐州市柔性引进高层次卫生人才项目 (2018210004)。 |
摘要
采用光镜及免疫组织化学的方法回顾性分析2例肾平滑肌肿瘤的临床病理学特征并复习相关文献。2名患者均为女性，因体检无意中发现，镜下肿瘤细胞短梭形或卵圆形，未见明确坏死，核分裂象少见，肿瘤细胞表达SMA、Desmin、Vimentin，不表达Ckpan、CAM5.2、CD10、HMB45、Melan-A、WT-1、CD34、CD99、STAT6。肾平滑肌瘤是一种少见肾间叶源性肿瘤，术前影像学不具有特异性且镜下形态易与其他梭形细胞肿瘤相混，其确诊依赖于病理特征及免疫表型。
关键词：
肾；间叶源性肿瘤；平滑肌瘤；鉴别诊断
Clinicopathological analysis of renal smooth muscle tumors: Two cases’ reports
CorrespondingAuthor: LIU Hui Email: hliu@xzhmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2022.03.038
Foundation: Xuzhou City Flexible Introduction of High-level Health Talents Project, China (2018210004).
Abstract
Clinical and pathological characteristics of 2 cases of renal smooth muscle tumors were retrospectively analyzed by HE and IHC. In addition, associated literatures were reviewed. Both of the two patients were female with tumor cells found to be short fusiform or oval under the microscope, with rare mitotic figures and no necrosis. Tumor cells expressed SMA, Desmin and Vimentin, but did not express Ckpan, CAM5.2, CD10, HMB45, Melan-A, WT-1, CD34, CD99 or STAT6. Renal leiomyoma is a rare renal mesenchymal tumor. Preoperative imaging is not specific and its morphology may easily lead to a misdiagnosis with other spindle cell tumors. Thus, the diagnosis of renal smooth muscle tumors depends both on pathological characteristics and immunophenotype.
Keywords：
kidney; mesenchymal tumor; leiomyoma; differential diagnosis