血清和糖皮质激素诱导的蛋白激酶在恶性肿瘤中的作用
| 作者: |
1侯力,
2孟峻
1 内蒙古医科大学附属医院临床检验诊断学教研室，呼和浩特 010059 2 内蒙古医科大学附属医院检验科，呼和浩特 010050 |
| 通讯: |
孟峻
Email: nmfrank@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.05.032 |
| 基金: | 国家自然科学基金(81360109，81660267)。 |
摘要
血清和糖皮质激素诱导的蛋白激酶(serum and glucocorticoid-induced protein kinase，SGK)是一种丝氨酸/苏氨酸双特异性蛋白激酶，由3种亚型(SGK1、SGK2及SGK3)组成，3个亚型具有高度同源性，但是功能各不相同。SGK的3种亚型与肿瘤生长、转移、自噬及上皮离子转运的调节有关。SGK与蛋白激酶B(PKB/AKT)有相似的结构、功能和底物特异性，与AKT一样，也是在磷脂酰肌醇3-激酶(PI3K)通路的下游被激活，该途径由3-磷酸肌醇依赖性蛋白激酶1(3-phosphate inositol dependent protein kinase 1，PDK1)和哺乳动物雷帕霉素靶蛋白复合体2(mammalian target of rapamycin complex 2，mTORC2)介导。PI3K可以通过依赖SGK，但不依赖蛋白激酶B(PKB/AKT)的机制在肿瘤的发生中起作用，在许多癌症中SGK表达水平显著增加已得到证实。因此，SGK可能是一个潜在的抗癌治疗靶点。
关键词：
血清和糖皮质激素诱导的蛋白激酶；磷脂酰肌醇3-激酶；恶性肿瘤；信号通路
Role of serum and glucocorticoid-induced protein kinases in malignant tumors
CorrespondingAuthor: MENG Jun Email: nmfrank@163.com
DOI: 10.3978/j.issn.2095-6959.2022.05.032
Foundation: This work was supported by the National Natural Science Foundation of China (81360109, 81660267).
Abstract
Serum and glucocorticoid-induced protein kinase (SGK) is a serine/threonine bispecific protein kinase, composed of 3 subtypes (SGK1, SGK2 and SGK3). The 3 subtypes are highly homologous, but have different functions. The 3 subtypes of SGK are related to the regulation of tumor growth, metastasis, autophagy, and epithelial ion transport. SGK is similar to protein kinase B (PKB/AKT) in structure, function and substrate specificity. Like AKT, it is also activated by the downstream of phosphatidylinositol 3-kinase (PI3K) pathway, which is mediated by 3-phosphate inositol dependent protein kinase 1 (PDK1) and mammalian target of rapamycin complex 2 (mTORC2). PI3K can play a role in tumorigenesis through a SGK-dependent but PKB/AKT-independent mechanism, and it has been confirmed that the expression of SGK is significantly increased in many cancers. Therefore, SGK may be a potential target for anticancer therapy.
Keywords：
serum and glucocorticoid-induced protein kinase; PI3K; malignant tumor; signal pathway