FAP-α和VEGF在卵巢癌中的表达及意义
| 作者: |
1单丽辉,
1杨志蓉,
1莫云路,
1赵颖洁,
2刘丽萍,
1易小恋,
3胡兵
1 四川省妇幼保健院病理科，成都 610031 2 石棉县人民医院病理科，四川 雅安 625400 3 重庆市黔江中心医院病理科，重庆 409000 |
| 通讯: |
胡兵
Email: 47784108@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.03.003 |
| 基金: | 国家重点研发计划(2017YFC0907304)。 |
摘要
目的：检测卵巢癌组织中纤维母细胞活化蛋白-α(fibroblast activation protein α，FAP-α)和血管内皮生长因子(vascular endothelial growth factor，VEGF)的表达情况，探讨其与卵巢癌侵袭和转移的关系。方法：应用免疫组织化学法检测80例卵巢癌组织和30例正常卵巢组织中FAP-α和VEGF的表达，并分析两者的相关性，探讨其与卵巢癌临床病理特征的关系。结果：卵巢癌组织中的FAP-α和VEGF均显著高于正常卵巢组织(P<0.05)；在卵巢癌中FAP-α主要表达于间质纤维母细胞细胞质，并且与分化程度、Figo分期、侵袭深度、淋巴结转移相关(P<0.05)，而与年龄、组织学分型无关(P>0.05)；在卵巢癌中VEGF主要表达于肿瘤细胞的细胞质，并且与分化程度、Figo分期、侵袭深度、淋巴结转移相关(P<0.05)，而与年龄、组织学分型无关(P>0.05)；在卵巢癌组织中FAP-α和VEGF表达呈正相关。结论：FAP-α和VEGF在卵巢癌的进展中起重要的作用，可为卵巢癌的治疗提供新的思路和作用靶点。
关键词：
纤维母细胞活化蛋白-α；血管内皮生长因子；癌相关纤维母细胞；卵巢癌
Expression of FAP-α and VEGF and their clinical significance in ovarian cancer
CorrespondingAuthor: HU Bing Email: 47784108@qq.com
DOI: 10.3978/j.issn.2095-6959.2022.03.003
Foundation: This work was supported by the National Key R&D Program of China (2017YFC0907304).
Abstract
Objective: To study the expression of fibroblast activation protein α (FAP-α) and vascular endothelial growth factor (VEGF) in ovarian cancer and their relationship with tumor invasion and metastasis. Methods: We used immunohistochemical technique to detect the expression of FAP-α and VEGF in 80 cases of ovarian cancer tissues and 30 cases of normal ovarian tissues, and analyzed its relationship with clinicopathological features. Results: There were statistically significant differences in the expression of FAP-α and VEGF between ovarian carcinoma and normal ovarian tissues (P<0.05); the expression of FAP-α was main in cancer-associated fibroblasts but VEGF was in cancer cells, both of them were associated with differentiation degree, Figo stage, depth of tumor invasion, and lymph node metastasis (P<0.05), but had no obvious relationship with ages and histological types. Positive correlation of FAP-α and VEGF protein expression was found in ovarian carcinoma. Conclusion: FAP-α and VEGF play an important role in the evolution of ovarian cancer, and will provide new idea and target for the treatment of ovarian cancer.
Keywords：
fibroblast activation protein α; vascular endothelial growth factor; cancer-associated fibroblasts; ovarian cancer