Objective: To study the effect of rapid rehabilitation surgical nursing on stress response and postoperative recovery of patients undergoing different laparoscopic adrenal surgery. Methods: Seventy patients undergoing laparoscopic adrenalectomy from May 2017 to August 2020 were randomly divided into a control group and an observation group, with 35 cases in each group. The control group received routine nursing, while the observation group received rapid rehabilitation surgical nursing on the basis of the control group. Perioperative indicators, stress response, postoperative recovery and postoperative complications were compared between the observation group and the control group. Results: The perioperative indexes such as operation time, intraoperative blood loss, retention time of drainage tube and drainage volume in the observation group were significantly lower than those in the control group (P<0.05). The levels of epinephrine, norepinephrine, and cortisol in the observation group were significantly lower than those in the control group at the 10th min after the operation. The first exhaust time, the recovery time of gastrointestinal function, the time of getting out of bed, and the time of hospitalization in the observation group were significantly lower than those in the control group (P<0.05). The total incidence of postoperative complications in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: Rapid rehabilitation surgical nursing can significantly reduce stress reaction, accelerate postoperative recovery, reduce postoperative complications and improve clinical treatment effect of patients undergoing laparoscopic adrenal surgery after different approaches.