文章摘要

TRPM8在肿瘤中的研究进展

作者: 1冷傲, 2刘一谦, 1肖建如, 1钟南哲
1 上海长征医院骨肿瘤外科，上海 200003
2 上海长征医院医务中心，上海 200003
通讯: 肖建如 Email: jianruxiao83@163.com
钟南哲 Email: nanzhezhong@outlook.com
DOI: 10.3978/j.issn.2095-6959.2022.03.030
基金: 国家自然科学基金(8170100698;81902731)。

摘要

自2001年首次在前列腺癌中发现冷及薄荷醇感受器以来，人们不断意识到TRPM8在肿瘤的发生和发展过程中具有重要作用。TRPM8在多种肿瘤中的表达水平明显升高，并参与肿瘤的增殖、转移和免疫逃逸过程。本文拟对TRPM8在肿瘤增殖、迁移、凋亡和细胞自噬中的作用及分子机制作一综述。
关键词： 冷及薄荷醇感受器；肿瘤；分子机制

Research progress of TRPM8 in tumor

Authors: 1LENG Ao, 2LIU Yiqian, 1XIAO Jianru, 1ZHONG Nanzhe
1 Department of Orthopedic Oncology, Changzheng Hospital, Shanghai 200003, China
2 Department of Medical Affairs, Changzheng Hospital, Shanghai 200003, China

CorrespondingAuthor: XIAO Jianru Email: jianruxiao83@163.com

DOI: 10.3978/j.issn.2095-6959.2022.03.030

Foundation: This work was supported by the National Natural Science Foundation of China (8170100698; 81902731).

Abstract

Since its first identification in 2001, TRPM8 has made its implication gradually recognized in cancer development and progression. Subsequent studies have verified an upregulation of TRPM8 in various malignances, and revealed its promoting role in tumor proliferation, metastasis, and immune evasion. The aim of this review is to summarize the role of TRPM8 in tumor proliferation, metastasis, apoptosis and autophagy as well as its molecular mechanism.
Keywords： TRPM8; tumor; molecular mechanism

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