Objective: To investigate the clinicopathological characteristics, diagnosis, and differential diagnosis of minute pulmonary meningothelial-like nodules (MPMN). Methods: Forty-three cases of MPMN were collected from December 2017 to December 2019 at the First Affiliated Hospital of Guangzhou Medical University. All cases were retrospectively studied by hematoxylin and eosin (HE) staining and immunohistochemistry (IHC). The clinicopathological features were reviewed. Results: Forty-three MPMNs were identified from 8 034 patients underwent pulmonary resection. There were 5 males and 38 females with a male to female ratio of 1 to 7.6. The age ranged from 41–77 years, with a mean age 60 years. There were 35 cases (81.3%) accompanied with lung adenocarcinoma, 5 cases (11.6%) with atypical adenomatous hyperplasia (AAH), and 3 cases (6.9%) with benign pulmonary lesions, including pulmonary bullae, pulmonary arteriovenous fistula, and interstitial pneumonia. The diameter of lesions ranged from 0.5 to 7 mm, with an average diameter of 2.2 mm. Lesions less than 3 mm were unconspicuous on CT, whereas lesions larger than 3 mm showed ground-glass opacity on CT. Histologically, epithelioid cells and short spindle cells are arranged in a nested or whorls shape, with oval nuclei, intranuclear inclusions and unconspicuous nucleolus. Tumor cells diffusely express somatostatin receptor 2a (SSTR2a), Vimentin, PR, EMA. Conclusion: MPMN tends to occur in elderly women, and most cases are often accompanied with lung adenocarcinoma. The histomorphology and immunohistochemical phenotype are similar to meningioma. The positive expression of immunohistochemical markers SSTR2a, Vimentin, PR, EMA would support the diagnosis of MPMN.