Objective: To investigate the effect of homemade dietary nutrition prescription on elderly patients with chronic heart failure. Methods: A total of 100 elderly patients with chronic heart failure who were admitted to our hospital from January 2018 to December 2019 were selected and divided into two groups according to the random number table method, 50 cases each. The control group was given routine dietary intervention, and the observation group was given homemade dietary nutrition prescription intervention. The clinical efficacy, nutritional status, quality of life, and prognosis of the two groups were compared. Results: The total clinical effective rate of the observation group was higher than that of the control group; the levels of Alb, PA, TF and Hb of the observation group were higher than those of the control group 6 months after the intervention; the readmission rate and mortality rate of the observation group were lower than those of the control group; the total scores of physical field, social economy, emotional field and quality of life of the observation group 6 months after the intervention were lower than those of the control group, with statistical significance (P<0.05). Conclusion: The homemade dietary nutrition prescription intervention has obvious clinical effects in elderly patients with chronic heart failure, which can improve the quality of life, nutritional status and prognosis of chronic heart failure.