Objective: To explore the effects of continuous epidural labor analgesia on labor pain, labor process and maternal and infant outcomes in pre-eclampsia pregnant women. Methods: A total of 84 pregnant women with preeclampsia who delivered in our hospital from May 2018 to May 2020 were randomly divided into observation group and control group, 42 cases in each group. The control group received routine delivery, while the observation group received continuous epidural analgesia delivery. The Visual Analogue Scale (VAS) score, mean arterial pressure (MAP), labor time, delivery mode, and maternal and infant delivery outcomes were compared between the two groups. Results: After analgesia, VAS pain scores in the first and second stages of labor in the observation group were lower than those in the control group (P<0.05). After analgesia, MAP at 10 cm of uterine opening and delivery was significantly lower than that of the control group (P<0.05). After analgesia, the first and second stages of labor in the observation group were shorter than those in the control group (P<0.05), and there was no difference in the third stage of labor (P>0.05). After analgesia, the usage rate of oxytocin and vaginal delivery rate in the observation group were higher than those in the control group (P<0.05), while the cesarean section rate, fetal distress rate, postpartum complications rate and postpartum hemorrhage of pregnant women were lower than those in the control group (P<0.05). There was no difference in Apgar score between the two groups after birth (P>0.05). Conclusion: Continuous epidural labor analgesia can reduce the pain of parturient and maintain the stability of blood pressure, and has no adverse effect on the time of labor, the mode of delivery and the outcome of both mother and infant.