Objective: To study the management of the emergency department, and epidemic prevention and control scheme protocol under the current situation of 2019 novel coronavirus pneumonia (hereinafter referred to as COVID-19). Methods: According to the work content of the emergency department of Chen Xinghai Hospital, combined with the emergency diagnosis and treatment, the protection requirements and disinfection standards in COVID-19, the specific work content of the emergency department management and epidemic prevention and control plan are formulated. Specifically, the plan included human resources management, protective materials management, diagnosis and treatment management of fever patients, diagnosis and treatment and protection management of other emergency patients, protection management of medical staff, protection management of patients’ families and disinfection management. After epidemic control, the effect was evaluated, and the mental health of medical staff before and after the control was compared by the Symptom Checklist 90 (SCL-90). The awareness of epidemic prevention of patients’ families was compared by the examination papers of epidemic prevention knowledge, and the disinfection quality of high-frequency contacts was recorded. Results: Based on COVID-19 situation, the emergency department formulated scientific management plans and effective prevention and control strategies and strictly implemented them, so that human resources were rationally allocated, and medical materials were supplied and effectively utilized. Before and after control, the mental health status of medical staff was compared by the SCL-90. The results showed that SCL-90 score after control was significantly higher than that before control (136.01±43.50 vs 126.25±38.54; P<0.05). After control, the score of epidemic prevention knowledge examination paper was significantly higher than that before control (85.71±13.44 vs 72.15±8.39; P<0.05). The qualified rate of disinfection of high-frequency contacts was 100.0%. After epidemic control, disinfection work was put in place, patient diagnosis and treatment work was carried out in an orderly manner, and there was no cross-infection in hospital. Conclusion: During the COVID-19, strengthening scientific management and prevention and control in the emergency department is of great significance to the normal operation of diagnosis and treatment and the prevention of cross-infection.