文章摘要

完整结肠系膜切除术治疗老年结肠癌的近期疗效

作者: 1吴晖, 1刘子君, 1曹红勇
1 南京医科大学附属南京医院(南京市第一医院)普通外科,南京 210000
通讯: 曹红勇 Email: caohongy6167@163.com
DOI: 10.3978/j.issn.2095-6959.2021.05.008

摘要

目的:分析完整结肠系膜切除(complete mesocolic excision,CME)术治疗老年结肠癌的近期疗效及对血清肿瘤标志物的影响。方法:选定南京市第一医院2016年9月至2019年9月收治的165例老年结肠癌患者,随机分为对照组(82例,采纳传统根治术治疗)与实验组(83例,采纳CME术治疗),对比两组手术指标、血清肿瘤标志物、并发症发生率、6个月内复发率。结果:实验组手术时间较对照组长(P<0.05);实验组术中出血量明显比对照组少,实验组术后首次排气时间、住院时间均显著短于对照组,实验组淋巴结清扫数量显著多于对照组(P<0.05)。实验组术后1个月血清CA199、SF、CEA、CA125水平均显著比对照组低,实验组并发症发生率(2.41%)、6个月内复发率(3.61%)均显著低于对照组(13.41%、23.17%;P<0.05)。结论:CME术短期内可有效改善老年结肠癌患者病情,抑制血清肿瘤标志物高表达,降低并发症发生率及复发率,疗效显著,值得借鉴。
关键词: 完整结肠系膜切除术;老年结肠癌;近期疗效;血清肿瘤标志物;并发症

Short-term efficacy of complete mesocolic excision for elder patients with colon cancer

Authors: 1WU Hui, 1LIU Zijun, 1CAO Hongyong
1 Department of General Surgery, Surgery, Nanjing Hospital Affiliated to Nanjing Medical University (Nanjing First Hospital), Nanjing 210000, China

CorrespondingAuthor: CAO Hongyong Email: caohongy6167@163.com

DOI: 10.3978/j.issn.2095-6959.2021.05.008

Abstract

Objective: To analyze the short-term efficacy of complete mesocolic excision (CME) in the treatment of senile colon cancer and its effect on serum tumor markers. Methods: A total of 165 elderly patients with colon cancer who were admitted to our hospital from September 2016 to September 2019 were randomly divided into two groups: 82 patients in the reference group were treated with traditional radical surgery, and 83 patients in the experimental group were treated with CME. The surgical indexes, serum tumor markers, complication rate and recurrence rate within 6 months were compared between the two groups. Results: The operation time of the experimental group was longer than that of the control group (P<0.05); the intraoperative bleeding volume of the experimental group was significantly lower than that of the reference group, the first postoperative exhaust time and hospitalization time of the experimental group were significantly shorter than that of the reference group, and the number of lymph node dissections in the experimental group significantly higher than the reference group (P<0.05). The levels of serum CA199, SF, CEA, and CA125 in the experimental group were significantly lower than those in the reference group at 1 month after operation. The incidence of complications in the experimental group (2.41%) and the recurrence rate within 6 months (3.61%) were significantly higher than those in the reference group (13.41%, 23.17%) low (P<0.05). Conclusion: CME can effectively improve condition of elderly colon cancer patients in the short term, suppress high expression of serum tumor markers, reduce incidence of complications and recurrence rate, and has a significant effect.
Keywords: complete mesocolic excision; elderly patient; colon cancer; short-term efficacy; serum tumor markers; complications