细胞程序性死亡在心肌梗死中的研究进展
| 作者: |
1郭雨桐,
1刘越,
1刘文秀
1 哈尔滨医科大学附属第一医院心内科，哈尔滨 150001 |
| 通讯: |
刘文秀
Email: hitlqn@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.02.028 |
| 基金: | 国家自然科学基金(81700318)；中国博士后科学基金(2018M631957)；黑龙江省博士后科学基金 (LBH-Z17145)；哈尔滨医科大学大学生创新创业训练计划(201910226157)。 |
摘要
心肌梗死(myocardial infarction，MI)在世界范围内被认为是导致心源性死亡的主要原因。MI会导致心脏多种结构和功能的损伤，形成心室重塑，导致心力衰竭、心律失常和心脏破裂，甚至死亡。细胞程序性死亡(programmed cell death，PCD)包括凋亡、焦亡、自噬和铁死亡等不同死亡形式，有别于坏死。研究发现PCD贯穿MI及其之后的心肌损伤和心室重塑等发病过程，在MI的发生发展中发挥重要的作用。
关键词：
心肌梗死；程序性死亡；焦亡；自噬；铁死亡
Research progress of programmed cell death in myocardial infarction
CorrespondingAuthor: LIU Wenxiu Email: hitlqn@126.com
DOI: 10.3978/j.issn.2095-6959.2022.02.028
Foundation: This work was supported by the National Natural Science Foundation (81700318), China Postdoctoral Science Foundation (2018M631957), Heilongjiang Postdoctoral Science Foundation (LBH-Z17145), and Innovation and Entrepreneurship Training Program for College Students of Harbin Medical University (201910226157), China.
Abstract
Myocardial infarction (MI) is the leading cause of cardiac death worldwide. MI can provoke the damage of many heart structures and functions, and form ventricular remodeling, resulting in heart failure, arrhythmia, heart rupture, and death. Programmed cell death (PCD), also known as regulated cell death, is a form of cell death including apoptosis, pyroptosis, autophagy and ferroptosis, which is different from necrosis. Studies have found that PCD runs through the process of MI and its myocardial injury and ventricular remodeling, plays an important role in the development of MI.
Keywords：
myocardial infarction; programmed cell death; pyroptosis; autophagy; ferroptosis