Objective: To analyze the correlation between serum levels of soluble growth ST immolation expressed gene 2 (sST2) and C-terminus (TN-C) and cardiovascular events in maintenance hemodialysis (MHD) patients. Methods: From March 2018 to March 2020, 94 patients with MHD in our hospital were collected as the MHD group. In addition, 51 healthy volunteers matched in age and gender were selected as the control group. The serum levels of sST2 and TN-C were compared between the 2 groups, and the related risk factors of MHD complicated with cardiovascular events were analyzed by multivariate logistic regression. In addition, receiver operating characteristic curve (ROC) was drawn to analyze the predictive value of serum sST2 and TN-C in MHD complicated with cardiovascular events. Results: The average levels of sST2 and TN-C in MHD group were significantly higher than those in control group (all P<0.05); there were 41 cardiovascular events in 94 patients with MHD, including arrhythmia, cardiac dysfunction, acute coronary syndrome, myocardial infarction and heart failure; univariate screening showed that age, dialysis time, CRP, sST2 and TN-C were associated with cardiovascular events; multivariate logistic regression analysis showed that age, dialysis time, CRP, sST2 and TN-C were independent risk factors of cardiovascular events in MHD patients; the ROC curve showed that serum sst2 had a high value in predicting cardiovascular events in MHD patients. The optimal critical value for predicting cardiovascular events was 58.6 μg/L and AUC was 0.800 (95%CI: 0.700–0.901). Conclusion: sST2 and TN-C are the independent influencing factors of cardiovascular events in MHD patients. The levels are significantly abnormal in MHD patients. Serum sST2 has higher predictive value for cardiovascular events in MHD patients.