脑白质高信号与阿尔茨海默病的相关性
| 作者: |
1铁涛,
1邓美霞,
1石亚玮,
1王力群,
1蔡宏斌,
1石正洪
1 兰州大学第二医院神经内科，兰州 730000 |
| 通讯: |
石正洪
Email: lzuedut@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.03.036 |
| 基金: | 兰州市科技计划项目 (2016-3-118)。 |
摘要
脑白质高信号(white matter hyperintensity，WMH)为磁共振成像(magnetic resonance imaging，MRI)中T2加权像(T2 weighted imaging，T2WI)或T2液体衰减反转恢复序列(fluid attenuation inversion recovery，FLAIR)中的高信号影，其也称为脑白质病变或脑白质疏松。WMH可能成为阿尔茨海默病(Alzheimer’s disease，AD)的生物标志物，预测AD的发生与进展。WMH与AD病理可能存在某种相互作用，但仍需更多研究来明确。WMH在AD的早期阶段可预测认知功能的变化，但随着AD病程的进展，AD病理对认知功能的影响将起主要作用。脑白质微观结构的检测可以早期发现脑白质病变，并为疾病早期阶段发现AD做好准备。
关键词：
阿尔茨海默病；脑白质高信号；认知障碍
Correlation between white matter hyperintensity and Alzheimer’s disease
CorrespondingAuthor: SHI Zhenghong Email: lzuedut@163.com
DOI: 10.3978/j.issn.2095-6959.2022.03.036
Foundation: This work was supported by Lanzhou Science and Technology Plan Project, China (2016-3-118).
Abstract
White matter hyperintensity (WMH) has areas of increased signal on T2 weighted imaging (T2WI) or fluid attenuation inversion recovery (FLAIR), which is also called white matter lesion or leukoaraiosis. WMH could become a biomarker of Alzheimer’s disease (AD) and predict the occurrence and progression of AD. There is likely to be some interaction between WMH and AD pathology, but more researches are needed to clarify this interaction. WMH can predict the change of cognitive function in the early stage of AD. However, with the development of AD, the impact of AD pathology on cognitive function will play a major role. The detection of white matter microstructure can discover white matter lesions early and prepare for the predictions of AD in the early stage of the disease.
Keywords：
Alzheimer’s disease; white matter hyperintensity; cognitive impairment