Objective: To explore the effect of enhanced recovery after surgery (ERAS) in the perioperative period of pelvic floor dysfunction. Methods: A total of 90 patients with pelvic floor dysfunction disease, who were admitted to our hospital from March 2019 to March 2020, were selected and divided into two groups (each with 45 cases) with the random number table method. The control group underwent a routine perioperative management, and the observation group underwent a perioperative management in ERAS. The surgical indicators and, postoperative recovery, negative emotions, quality of life, and incidence of complications were compared between the 2 groups. Results: Compared with the control group, the operation time and intraoperative blood loss of the observation group were not statistically significant (P>0.05); the time of the first postoperative exhaustion, the time of the first bowel movement, the time of the first meal, the time of the first out of bed, the hospitalization time was shorter than that of the control group (P<0.05); the postoperative SAS and SDS assessments of the observation group were lower than that those of the control group (P<0.05); the postoperative PFDI-20 and PFIQ-7 scores of the observation group were lower than that those of the control group, PISQ-31 score was higher than the control group (P<0.05); the total postoperative complication rate of the observation group was lower than the control group (P<0.05). Conclusion: The application of ERAS in the perioperative period of pelvic floor dysfunction diseases can improve the quality of life of patients, reduce negative emotions, promote postoperative recovery, and reduce complications.