Objective: To investigate the effects of statins and their treatment intensity on platelet aggregation in patients with acute ischemic stroke. Methods: Sixty patients with acute cerebral infarction in Anyang People’s Hospital were randomly selected. The observation group (36 cases) were those who had received statins before admission and continued to be treated with statins, and the control group (24 cases) had never received anything within 3 months Statins. Dynamic platelet function tests were performed on two groups of patients to observe the effect of statins on platelet aggregation. In order to further observe the effect of statin treatment intensity on platelet aggregation function, the observation group was divided into two subgroups of medium intensity and high intensity according to the intensity of statin treatment, and dynamic platelet function tests were performed respectively. Results: The maximum platelet aggregation rate (AA-MAR) induced by arachidonic acid in the observation group and the control group were 21.56±12.02 and 29.43±21.60, respectively, and the difference was not statistically significant (t=1.625, P=0.114); The maximum platelet aggregation rate (ADP-MAR) induced by adenosine diphosphate in the observation group and control group were 25.31±12.38 and 34.50±13.50, respectively, and the difference was statistically significant (t=2.717, P=0.009). The results of correlation analysis showed that the use of statins was significantly negatively correlated with ADP-MAR levels (P=0.006). No correlation between the intensity of statin treatment and platelet aggregation rate was found. Conclusion: Statins can significantly reduce ADP-MAR. The effect of statin on AA-ADP and the effect of statin treatment intensity on platelet aggregation function have not been observed.