文章摘要

他汀类药物对急性缺血性脑卒中患者血小板聚集功能的影响

作者: 1刘舒扬, 2张建刚, 3苏钰, 4朱曼
1 安阳市人民医院临床药学科,河南 安阳 455000
2 安阳市人民医院神经内科,河南 安阳 455000
3 安阳市人民医院药理实验室,河南 安阳 455000
4 安阳市肿瘤医院检验科,河南 安阳 455000
通讯: 刘舒扬 Email: Dqyangzizi@163.com
DOI: 10.3978/j.issn.2095-6959.2021.05.012

摘要

目的:探讨他汀类药物及其治疗强度对急性缺血性脑卒中患者血小板聚集功能的影响。方法:随机选取安阳市人民医院60例急性脑梗死患者,观察组(36例)为入院前已接受他汀类药物并继续应用他汀类治疗者,对照组(24例)为3个月内从未接受过任何他汀类药物者。对两组患者进行动态血小板功能检测,观察他汀类药物对血小板聚集功能的影响。为进一步观察他汀类治疗强度对血小板聚集功能的影响,将观察组按照接受他汀类药物的治疗强度分为中等强度和高强度两个亚组,分别进行动态血小板功能检测。结果:观察组和对照组患者花生四烯酸(AA)诱导下的血小板最大聚集率(AA-MAR)分别为21.56±12.02和29.43±21.60,差异无统计学意义(t=1.625,P=0.114);观察组和对照组患者二磷酸腺苷(ADP)诱导下的血小板最大聚集率(ADP-MAR)分别为25.31±12.38和34.50±13.50,差异具有统计学意义(t=2.717,P=0.009)。应用他汀类药物与ADP-MAR水平呈显著性负相关(P=0.006)。未发现他汀治疗强度与血小板聚集率的相关性。结论:他汀类药物显著降低ADP-MAR,未观察到他汀对AA-ADP的影响,以及他汀治疗强度对血小板聚集功能的影响。
关键词: 他汀类;急性缺血性脑卒中;血小板聚集率;花生四烯酸;二磷酸腺苷

Effect of statins on platelet aggregation function in patients with acute ischemic stroke

Authors: 1LIU Shuyang, 2ZHANG Jiangang, 3SU Yu, 4ZHU Man
1 Department of Clinical Medicine, Anyang People's Hospital, Anyang, Henan 455000, China
2 Department of Neurology, Anyang People's Hospital, Anyang, Henan 455000, China
3 Department of Clinical Pharmacy, Anyang People's Hospital, Anyang, Henan 455000, China
4 Department of Laboratory Medicine, Anyang Cancer Hospital, Anyang , Henan 455000, China

CorrespondingAuthor: LIU Shuyang Email: Dqyangzizi@163.com

DOI: 10.3978/j.issn.2095-6959.2021.05.012

Abstract

Objective: To investigate the effects of statins and their treatment intensity on platelet aggregation in patients with acute ischemic stroke. Methods: Sixty patients with acute cerebral infarction in Anyang People’s Hospital were randomly selected. The observation group (36 cases) were those who had received statins before admission and continued to be treated with statins, and the control group (24 cases) had never received anything within 3 months Statins. Dynamic platelet function tests were performed on two groups of patients to observe the effect of statins on platelet aggregation. In order to further observe the effect of statin treatment intensity on platelet aggregation function, the observation group was divided into two subgroups of medium intensity and high intensity according to the intensity of statin treatment, and dynamic platelet function tests were performed respectively. Results: The maximum platelet aggregation rate (AA-MAR) induced by arachidonic acid in the observation group and the control group were 21.56±12.02 and 29.43±21.60, respectively, and the difference was not statistically significant (t=1.625, P=0.114); The maximum platelet aggregation rate (ADP-MAR) induced by adenosine diphosphate in the observation group and control group were 25.31±12.38 and 34.50±13.50, respectively, and the difference was statistically significant (t=2.717, P=0.009). The results of correlation analysis showed that the use of statins was significantly negatively correlated with ADP-MAR levels (P=0.006). No correlation between the intensity of statin treatment and platelet aggregation rate was found. Conclusion: Statins can significantly reduce ADP-MAR. The effect of statin on AA-ADP and the effect of statin treatment intensity on platelet aggregation function have not been observed.
Keywords: statins; acute ischemic stroke; platelet aggregation rate; arachidonic acid; adenosine diphosphate