Acupoint stimulation is an important field in modern medicine, which plays an active role in regulating organ function and remodeling physiological homeostasis. Percutaneous acupoint stimulation has been recognized by the World Health Organization and has unique advantages in anti-inflammation and analgesia. In recent years, studies have found that acupoint stimulation can activate specific neural networks to achieve organ function protection and relieve inflammation, which provides strong evidence for the clinical significance of acupoint stimulation in controlling inflammation in the nervous system and infectious and inflammatory diseases. However, the specific mechanism of acupoint stimulation is not yet clear, and a large number of studies have shown that the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system may play an important regulatory role in the process by which acupoint stimulation works. This paper discusses the specific regulatory role of acupoint stimulation in the inflammatory response and the specific mechanism of the HPA axis and autonomic nervous system and analyzes the regulatory mechanism of acupoint stimulation on the neuronal network and the body’s inflammatory response.