In this paper, the clinicopathological features, diagnosis and differential diagnosis of two cases of metastatic gastric cancer to the uterus were discussed. Case 1 is a 40-year-old female who was hospitalized with light vaginal bleeding. The pathology showed the tumor cells were located in the superficial endometrial stroma, with focal distribution. The tumor cells had similar size and shape, mild-moderate atypia, and acidophilic cytoplasm. Nucleolus could be seen in some cells. Mitotic activity was rare. In some areas, endometrial glands were involved. Immunohistochemistry showed that the tumor cells were positive to CEA, MUC6, MUC5AC, CK18, CK7, CK20, CDX2 and other original markers of digestive system, while negative to ER, PR and PAX8. D-240 staining showed lymph vessel tumor emboli. After endoscopic examination and biopsy, poorly differentiated gastric adenocarcinoma was confirmed. Case 2 is a 47-year-old female with vaginal bleeding too. Unlike case 1, she had a history of gastric cancer. The biopsy revealed adenoid or scattered tumor cells in the interstitium of the cervix. Immunohistochemistry showed that the cells were positive to CK, CK20, CDX2, and other original markers of the digestive system. The case of gastric cancer metastatic to uterus is rare. In some cases, the patients present with vaginal bleeding but without a history of gastric cancer are easily misdiagnosed or never diagnosed. To avoid misdiagnosis, it is important for us to be fully aware of this carcinoma and apply immunohistochemistry to differential diagnosis.