Objective: To explore the application of medical application (APP) in extended rehabilitation nursing for patients with replantation of severed finger and its influences on function recovery of replanted fingers and satisfaction of the patients. Methods: A total of 59 patients who underwent finger re-plantation and were admitted to the Hefei Second People’s Hospital from January 2019 to January 2020 were enrolled as the research objects. According to random number table method, they were divided into the control group (n=30) and the observation group (n=29). The control group was given routine extended rehabilitation nursing, while medical APP was applied in observation group for extended rehabilitation nursing on basis of control group. The function recovery of replanted fingers, self-efficacy, self-care ability, incidence of complications and nursing satisfaction before and after intervention were compared between the two groups. Results: The function recovery of replanted fingers in observation group was better than that in control group (P<0.05). After intervention, scores of common disease management and symptom management in observation group were higher than those in control group (P<0.05); scores of health knowledge level, self-care skills, self-concept and self-care responsibility were higher than those in control group (P<0.05). The incidence of complications in observation group was lower than that in control group (6.67% vs 26.67%) (P<0.05). The scores of professional skill, service management, service attitude, and patient care in observation group were all higher than those in control group (P<0.05). Conclusion: The application of medical APP in extended rehabilitation nursing is beneficial to restore the function of patients’ replanted fingers, improve their self-efficacy and self-care ability, reduce occurrence of complications and improve satisfaction of patients.