Objective: To explore the effect of cluster nutrition care on nutritional indexes and immune level in patients with neoadjuvant chemotherapy for gastric cancer. Methods: A total of 40 patients with neoadjuvant chemotherapy for gastric cancer in Liaoning Cancer Hospital from January to June 2019 were included as a control group that received routine nutritional care. Totally 42 patients with neoadjuvant chemotherapy for gastric cancer in Liaoning Cancer Hospital from July to December 2019 were included as an observation group that received cluster nutrition care. The nutritional indexes and immune levels of the 2 groups were compared after 3 courses of chemotherapy. Results: Hemoglobin (Hb) and albumin (ALB) of the observation group after 3 courses of chemotherapy were higher than those of the control group, and body mass index (BMI) was higher than that of the control group as well, and the difference was statistically significant (P<0.05). The nutritional risk of the observation group after 3 courses of chemotherapy was lower than that of the control group, and the difference was statistically significant (P<0.05). After 3 courses of chemotherapy, CD4⁺ and CD4⁺/CD8⁺ in the observation group were higher than those in the control group, and CD8⁺ in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion: Cluster nutrition care can reduce the nutritional risk of patients with neoadjuvant chemotherapy for gastric cancer, improve the nutritional indicators during chemotherapy, and immune function.