口腔用复合树脂细胞毒性的研究进展
| 作者: |
1张静怡,
1李丹薇,
1雷雅燕
1 昆明医科大学附属口腔医院牙体牙髓病科，昆明 650106 |
| 通讯: |
李丹薇
Email: 89402424@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.11.028 |
| 基金: | 云南省教育厅科学研究基金(2018JS234)。 |
摘要
复合树脂具有良好的修复效果，临床上应用广泛。研究表明树脂基材料中未完全反应的残留单体具有严重的细胞毒性和遗传毒性，造成细胞功能不可逆性损伤。但由于复合树脂生物相容性和粘接性良好、美观性好、操作性强、修复时间短，且树脂弹性模量接近牙本质，用树脂充填后，牙齿具有极好的抗折裂性，因此研究其对细胞的生物相容性具有很重要的临床意义，可为其临床应用提供科学依据，并为树脂材料的发展奠定基础。
关键词：
复合树脂；残留单体；细胞毒性；基因毒性
Research progress in cytotoxicity of oral composite resins
CorrespondingAuthor: LI Danwei Email: 89402424@qq.com
DOI: 10.3978/j.issn.2095-6959.2021.11.028
Foundation: This work was supported by the Scientific Research Fund Project of Yunnan Provincial Education Department, China (2018JS234).
Abstract
Composite resins have been widely used clinically because of their good repair effects. Studies have shown that incompletely reacted residual monomers in resin-based materials can cause serious cytotoxicity and genotoxicity, and cause irreversible damage to cell functions. However, composite resin has good biocompatibility and adhesion, good aesthetics, strong operability, and short repair time, and its elastic modulus is close to dentin. After being filled with resin, the teeth have excellent resistance to bending. Therefore, the study of its biocompatibility to cells has important clinical significance, which can provide scientific basis for its clinical application and lay a foundation for the development of resin materials.
Keywords：
composite resin; residual monomer; cytotoxicity; genotoxicity