Objective: To evaluate the clinical application of domestic self-tapping micro-titanium nail as anchorage in the retraction of anterior teeth treatment. Methods: A total of 19 patients with Angle I & Angle II malocclusion, maxillary protrusion or bi-maxillary protrusion were selected. The orthodontic treatment was the extraction of the bilateral first premolares and the anchorage was designed to be a strong one for the molars. Micro-titanium nails were used to implant into the alveolar space between the buccal root apexes of the maxillary first molar and the second premolar. The extraction space was closed by using sliding mechanics combined with Straight Arch wire Techniques. Sliding mechanics with a force of 150~200 g was used to retract anterior teeth. Based on the anterior skull base plane and the location of implant anchorage, the cephalometric films before and after treatment were compared, and the retraction of anterior teeth and the change of molar anchorage were measured. Results: Dental arch protrusion was improved significantly in 19 patients. The incisal edge of incisors was retracted (6.73±1.83) mm and the anchor molar moved anteriorly 0.8 mm averagely. It shows that maximum anchorage was achieved in all cases. Conclusion: The domestic self-tapping micro-titanium nail implant anchorage is a stable orthodontic anchorage. It is easy to operate, independent of patients’ collaboration, and it could control the anchorage of posterior teeth efficiently, retract the dental arch protrusion to the maximum extent, and therefore, expand the scope of orthodontic treatment.