内质网应激在胃癌中的研究进展
| 作者: |
1杨琛,
1卢德露,
2陈永林
1 兰州大学第一临床医学院，兰州 730000 2 兰州大学第一医院病理科，兰州 730030 |
| 通讯: |
陈永林
Email: pathology88@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.12.035 |
摘要
胃癌是全球最常见的恶性肿瘤之一，发病率及病死率极高。内质网应激(endoplasmic reticulum stress，ERS)通路的调节作用对于胃癌进展及治疗至关重要。幽门螺杆菌(Helicobacter pylori，Hp)及EB病毒(Epstein-Barr virus，EBV)与ERS信号通路相互作用可促进胃癌的进展。内质网伴侣蛋白78(glucose-regulated protein 78，GRP78/BiP)也可以促进胃癌的增殖与转移，并增强其耐药性。此外，ERS还能够通过加快上皮-间充质转化(epithelial-mesenchymal transition，EMT)促进肿瘤侵袭。因此，靶向ERS通路关键调节因子的药物来控制胃癌的研究，可以为胃癌治疗提供新方向。
关键词：
内质网应激；胃癌；幽门螺杆菌；EB病毒；内质网伴侣蛋白78；上皮-间充质转化
Research progress of endoplasmic reticulum stress in gastric cancer
CorrespondingAuthor: CHEN Yonglin Email: pathology88@163.com
DOI: 10.3978/j.issn.2095-6959.2021.12.035
Abstract
Gastric cancer is one of the most common cancers in the world, with high incidence rate and mortality rate. The regulation of endoplasmic reticulum stress (ERS) pathway is crucial for the progress and treatment of gastric cancer. The interaction of Helicobacter pylori (Hp) and Epstein-Barr virus (EBV) with ERS signaling pathway can promote the progression of gastric cancer. Glucose-regulated protein 78 can also promote the proliferation and metastasis of gastric cancer, and then enhance its drug resistance. In addition, ERS can promote tumor invasion by accelerating epithelial-mesenchymal transition. Therefore, the study of drugs targeting key regulators of the ERS pathway to control gastric cancer can provide a new direction for gastric cancer treatment.
Keywords：
endoplasmic reticulum stress; gastric cancer; Helicobacter pylori; Epstein-Barr virus; glucose-regulated protein 78; epithelial-mesenchymal transition