Objective: To study the effect of the Propess combined with oxytocin on pregnancy outcome in late pregnancy. Methods: A total of 329 cases of pregnant women with indications of induced labor in the third trimester of pregnancy from July 2018 to June 2019 in our hospital were selected and randomly divided into two groups. 165 cases in the control group were given oxytocin, and 164 cases in the observation group were treated additionally with Propess. The effect of promoting cervical ripening, the time from medication to induced labor and the total labor process were recorded; the time from medication to labor, and the stages, methods and outcomes of labor between the two groups were compared. Results: The time from the onset of medication to labor in the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). The first stage of labor, the second stage of labor and the total stage of labor in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05). The conversion rate of cesarean section in the observation group was 17.07%, which was significantly lower than 32.73% of the control group (P<0.05). The fetal distress rate and the incidence of neonatal adverse pregnancy outcomes in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of cervical laceration, vaginal laceration, uterine contraction, oligohydramnios, premature rupture of membranes, neonatal asphyxia, macrosomia and total adverse reactions between the two groups (P>0.05). Conclusion: The application of Propess combined with oxytocin in late pregnancy is more in line with the physiological changes of natural labor process, and can improve the pregnancy outcome.