Objective: To investigate the early evaluation of renal damage in patients with lupus nephritis (LN) by measuring the elasticity of renal parenchyma in patients with lupus nephritis by acoustic radiation force ultrasound elastography (ARFI). Methods: The left and right kidneys of 30 patients with lupus nephritis (the diseased group) and 30 healthy volunteers (the healthy group) were examined by routine ultrasound and elastic check, and the differences between the two groups were compared and analyzed. Receiver operating curves (ROC) were drawn and sensitivity, specificity, positive predictive value, and negative predictive value were calculated. Results: There was no significant difference in left and right kidney elasticity between the two groups (P>0.05). Taking the right kidney as an example, there was a significant difference in renal elasticity between the diseased group and the healthy group (P<0.05). Taking shear wave velocity (SWV) = 3.01 m/s as the cut-off value to diagnose the lupus nephritis, the area under the curve (AUC) was 0.898, and the sensitivity, specificity, positive predictive value and negative predictive value was 83.3%, 86.7%, 86.2% and 83.9% respectively. Conclusion: ARFI provides a new noninvasive evaluation method for the early diagnosis of lupus nephritis.