抗青光眼滤过手术后瘢痕化的研究进展
| 作者: |
1吴迪,
1张行,
1闫永钛,
1关立南
1 哈尔滨医科大学附属第一医院眼科医院眼科，哈尔滨 150001 |
| 通讯: |
关立南
Email: guanlinanvip@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.08.035 |
摘要
青光眼滤过手术是目前药物及激光治疗以外重要治疗方式，其目的在于形成功能性滤过通道，从而充分引流房水。但青光眼术后巩膜纤维化和结膜下滤泡瘢痕化是导致手术失败的重要原因。现从青光眼滤过手术后抗代谢药物、植入物应用、靶向机制、新型生物分子材料应用及表观遗传学研究5个方面来综合分析青光眼滤过手术后抗瘢痕化的进展现状。
关键词：
青光眼滤过手术；滤过通道；纤维化；抗瘢痕化药物；新型植入物；表观遗传学
Research progress on anti-scarring after glaucoma filtration surgery
CorrespondingAuthor: GUAN Linan Email: guanlinanvip@sina.com
DOI: 10.3978/j.issn.2095-6959.2021.08.035
Abstract
Glaucoma filtration surgery is an important treatment method besides drug and laser therapies. Its purpose is to form a functional filtering channel to fully drain aqueous humor. However, scleral fibrosis and subconjunctival follicle scarring after the surgery are important causes of surgical failure. This paper about anti-scaring after the glaucoma filtration surgery is structured from five aspects: antimetabolites, implant applications,targeting mechanisms, novel biomolecular materials applications, and epigenetic studies.
Keywords：
glaucoma filtration surgery; filtering channel; fibrosis; anti-scarring drugs; new implants; epigenetics