Objective: To explore the effect of chronic disease self-management program (CDSMP) on convalescent patients with cerebral infarction. Methods: A total of 150 cases of patients with cerebral infarction in Wujing community health service center, Minhang District from August 2018 to August 2019 were collected and divided into two groups according to the order of enrollment. The control group was managed according to the routine management mode, while the observation group was intervened according to chronic disease self-management program. They were evaluated with Questionnaire of Exercise Adherence, Fugl-Meyer Assessment (FMA), Modified Barthel Index (MBI), Self management behavior scale of stroke patients, Stroke-Specific Quality of Life Scale (SS-QOL) and General Self-Efficacy Scale (GSES) before and 6 months after intervention. Results: Before the intervention, there was no significant difference in the scores of each dimension and total score of questionnaire of exercise adherence, Self- management behavior scale of stroke patients, stroke-specific quality of life scale(SS-QOL), upper and lower limbs FMA scores, MBI scores and GSES (P>0.05). The scores of each dimension and total score of Questionnaire of Exercise Adherence, Self-Management Behavior Scale of stroke patients, SS-QOL, upper and lower limbs FMA scores, MBI scores of the observation group and GSES were higher than that of the control group 6 months after the intervention, and the difference was statistically significant (P<0.05). Conclusion: CDSMP intervention in convalescent cerebral infarction patients can improve their compliance of rehabilitation exercise and self- management behavior and self-efficacy, promote the recovery of limb function and improve the quality of life.