蛋白尿在慢性肾脏病进展中的新认识
| 作者: |
1李艳艳,
1范耀冰,
1吴红赤
1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150001 |
| 通讯: |
吴红赤
Email: 2674724077@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.06.027 |
| 基金: | 黑龙江省教育厅科学技术研究项目(12541264)。 |
摘要
慢性肾脏病(chronic kidney disease，CKD)是肾脏结构或功能的不可逆性改变。蛋白尿不仅是大多 数CKD患者共同的临床表现，而且在CKD的进行性发展中起重要作用。蛋白尿可通过诱导足细 胞损伤和凋亡等导致肾小球硬化；通过直接毒性作用、激活补体和炎性小体、诱导氧化应激、促 进凋亡等途径导致肾小管萎缩和间质纤维化。了解蛋白尿及其在CKD进展中的作用对于研究CKD 治疗新靶点和延缓CKD的进展具有重要意义。
关键词：
蛋白尿；慢性肾脏病；肾小管间质纤维化
New understanding of proteinuria in the progression of chronic kidney disease
CorrespondingAuthor: WU Hongchi Email: 2674724077@qq.com
DOI: 10.3978/j.issn.2095-6959.2021.06.027
Foundation: This work was supported by the Science and Technology Research Project of Heilongjiang Department of Education, China (12541264).
Abstract
Chronic kidney disease (CKD) is irreversible change in the structure or function of the kidney. Proteinuria is not only a common clinical manifestation in most CKD patients, but also plays an important role in the progressive development of CKD. Proteinuria can cause glomerular sclerosis by inducing podocyte damage and apoptosis; it can cause renal tubular atrophy and interstitial fibrosis through direct toxicity, activation of complement and inflammasome, inducing oxidative stress, and promoting apoptosis. Understanding proteinuria and its role in the progression of CKD is of great significance to the study of new therapeutic targets for CKD and the progression of delaying CKD.
Keywords：
proteinuria; chronic kidney disease; renal tubule interstitial fibrosis