Objective: To investigate the effect of elastography combined with thyroid hormone in the diagnosis of thyroid nodules and the influence on the ROC curve. Methods: Eighty-eight patients with suspected thyroid nodule from March 2018 to June 2019 were selected as the study group. All patients were confirmed by puncture and operation. Before diagnosis, all patients completed elastic imaging technology measurement; thyroid hormone (TSH) level was measured by full-automatic chemiluminescence method; 57 healthy people were selected as the control group; ROC curve was drawn. The diagnostic sensitivity and specificity of elastography combined with TSH in patients with thyroid nodules was analyzed. Results: Of the 88 suspected thyroid nodules, 51 were benign (57.95%) and 37 were malignant (42.05%). Eighty-five cases were finally diagnosed by elastic imaging technology, the coincidence rate with the diagnosis of surgical tissue was 96.59% (P>0.05); the TSH, fT3, fT4 and fT3/fT4 levels of thyroid nodule patients in the observation group were higher than those of the control group (P<0.05); the TSH, fT3, fT4 and fT3/fT4 levels of benign nodule patients in the observation group were lower than those of malignant nodule patients (P<0.05); the ROC curve results showed that: elastic formation The diagnostic sensitivity and specificity of imaging combined with thyroid hormone in patients with thyroid nodules were higher than that of single elastic imaging and thyroid hormone (P<0.05). Conclusion: The combination of elastography and thyroid hormone can help the diagnosis of thyroid nodule, and can obtain high sensitivity and specificity.