Objective: To study the intervention effect of predictive nursing on nausea and vomiting caused by cisplatin chemotherapy for lung cancer, and to provide guidance for patients’ nursing. Methods: From February 2018 to March 2019, 80 patients with lung cancer received cisplatin chemotherapy in our hospital were selected for study. According to the method of random number table, they were divided into a control group and an observation group. The nursing intervention was used in the control group and predictive nursing intervention was used in the observation group. The improvement of nausea and vomiting and the satisfaction rate of nursing were compared between the two groups. Results: The effective rates of nausea and vomiting improvement in the observation group (75.00%, 82.50%) were significantly higher than those in the control group (50.00%, 47.50%; P<0.05). The total satisfaction rate of the observation group (95.00%) was significantly higher than that of the control group (80.00%). The difference was statistically significant (χ2=4.114, P=0.042). Conclusion: Predictive nursing can effectively improve the immune function and reduce the nausea and vomiting caused by cisplatin chemotherapy in lung cancer.