Objective: Based on data mining, the prescription compatibility law of local acupoint selection about acupuncture for upper limb spastic paralysis after stroke (ULSPAS) was investigated, as to provide reference for clinical treatment. Methods: The clinical data of acupuncture for ULSPAS from January to June 2019 were collected from Chinese and English database, and acupuncture prescription database was established. Data description, association and cluster rules were analyzed by SPSS 21.0 and SPSS modeler 18.0 software. Results: A total of 237 acupuncture prescriptions are studied, including 65 acupoints of upper limb used for 1 519 times. The most frequently chosen acupoints were Hegu (LI4), Jianyu (LI15), Waiguan (SJ5), Quchi (LI11), Shousanli (LI10), and their multi-compatibility was used as main acupoints. While the core adjunct acupoints were Neiguan (PC6), Jiquan (HT1), Chize (LU5), Daling (PC7). Acupoints belongs to Meridian of Hand-Yangming, Meridian of Hand-Shaoyang and Meridian of Hand-Jueyin were most common, and specific acupoints takes majority, especially He-sea point. Conclusion: The general idea of acupuncture treating ULSPAS follows “Yangming first” and “Yin relieves spasm”, and rules of acupoint selection focus on specific acupoints and acupoints of spasmodic side, which may have a guiding effect on clinical practice.