Objective: To explore the effects of different anesthesia methods on intraoperative and postoperative analgesia and enhanced recovery after surgery in pediatric circumcision. Methods: From January 2018 to March 2019, a total of 231 children underwent circumcision in our hospital. A total of 141 children who were with certain disease, drug allergies, did not agree to participate in the study, and could not cooperate with local anesthesia were excluded in this study. Finally, 90 children undergoing circumcision in our hospital were prospectively enrolled. They were randomly divided into three groups: the intravenous anesthesia combined with ropivacaine and lidocaine sacral anesthesia group (group I), the intravenous anesthesia combined with ropivacaine sacral anesthesia group (group II), and the laryngeal mask anesthesia combined with ropivacaine sacral anesthesia group (group III). The surgical method was traditional resection and suture. The vital signs were monitored, the time from induction of anesthesia to the beginning of operation was recorded, the total times of analgesia postoperatively was calculated, and the pain score, motor block score, post-anesthesia care unit (PACU) stay, anesthesia cost and hospital stay were recorded. Results: The effect of anesthesia was satisfactory in all three groups, and the anesthesia method was not changed during the operation. The average operation time in group I, II and III was (30.23±6.22) min, (29.24±5.91) min, (29.94±5.59) min. There was no significant difference in the time from induction of anesthesia to the beginning of operation between the three groups (P=0.58). Children in groups I and II were sent to PACU after operation, while those in group III were sent to PACU after removal of laryngeal mask. There was no difference in propofol consumed during operation between group I and group II (P=0.573). Sevoflurane was maintained 1.0%–1.5% in group III. There was no difference between the postoperative PACU stay time (P=0.458) and hospital stay time (P=0.059). Compared with group II and III, group I had motor block at 30min after operation (P<0.001). No difference was found in postoperative nausea and vomiting between the three groups (P=0.455). There were seven patients (23.3%) with delirium, and 3 (10%) with increased excretions in group III. The cost of anesthesia in group III was nearly twice over those in group I and group II. Conclusion: Intravenous anesthesia combined with ropivacaine fistula block for pediatric circumcision can provide satisfactory anesthesia and postoperative analgesia, reduce complications and anesthesia cost, and promote the postoperative recovery of children.