IgA肾病进展的相关危险因素
| 作者: |
1刘杨,
1咸素贞,
1隋满姝
1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150000 |
| 通讯: |
隋满姝
Email: suimanshu@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.12.035 |
摘要
原发性免疫球蛋白A(immunoglobulin A，IgA)肾病是导致全球原发性肾小球肾炎的主要原因之一，其发病机制尚未完全阐明。目前研究报道自身免疫、遗传、环境因素和炎症等机制可能与IgA肾病相关。20%~40%的IgA肾病患者在20~30年内逐渐进展为终末期肾脏病。因此，识别IgA肾病进展的危险因素对于评估疾病进展以及预测IgA肾病患者预后具有重要的临床价值。
关键词：
IgA肾病；危险因素；慢性肾脏病
Risk factors related to the progression of IgA nephropathy
CorrespondingAuthor: SUI Manshu Email: suimanshu@163.com
DOI: 10.3978/j.issn.2095-6959.2020.12.035
Abstract
Primary IgA nephropathy (IgAN) is one of the leading causes of primary glomerulonephritis worldwide. Its pathogenesis has not yet been fully elucidated. It is considered that multi factors involved the causes of IgAN, such as autoimmune, genetic, environmental factors and inflammation activation mechanisms. And 20% to 40% of IgA nephropathy patients gradually progress to end-stage renal disease in 20–30 years. Therefore, it is of important clinical value to explore the risk factors for IgA progression, which can improve the accuracy of assessment of disease progression and prediction of prognosis.
Keywords：
IgA nephropathy; risk factors; chronic kidney disease