HIF-1α在心血管病中的作用
| 作者: |
1郑诗悦,
1杨阳,
1赵德超
1 哈尔滨医科大学附属第一医院心内科，哈尔滨 150001 |
| 通讯: |
赵德超
Email: drzhaodechao@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.05.026 |
摘要
缺氧诱导因子(hypoxia inducible factor，HIF)是缺氧诱导细胞所产生的一种蛋白质，包括HIF-1α和HIF-1β，其中HIF-1α参与了生物体的氧气供应、细胞代谢等病理生理过程，在心血管疾病中扮演重要的角色，如动脉粥样硬化、高血压、肺动脉高压、心肌病、先天性心脏病、心律失常等。
关键词：
缺氧诱导因子；心血管疾病；动脉粥样硬化；高血压；肺动脉高压；心肌病；先天性心脏病；心律失常
Role of HIF-1α in cardiovascular diseases
CorrespondingAuthor: ZHAO Dechao Email: drzhaodechao@163.com
DOI: 10.3978/j.issn.2095-6959.2021.05.026
Abstract
Hypoxia inducing factor (HIF) is a protein produced by hypoxia induced cells, including HIF-1α, and HIF-1β. HIF-1α is involved in the pathophysiological processes such as oxygen supply and cell metabolism. Meanwhile, HIF-1α plays an important role in cardiovascular diseases, such as atherosclerosis, hypertension, pulmonary hypertension, cardiomyopathy, congenital heart disease, and arrhythmia.
Keywords：
hypoxia inducing factor; cardiovascular diseases; atherosclerosis; hypertension; pulmonary hypertension; cardiomyopathy; congenital heart disease; arrhythmia