文章摘要

MiRNAs在成体神经发生中的作用

作者: 1朱红梅, 1张凤兰, 2戴海龙
1 昆明医科大学分子临床医学研究院,云南省干细胞和再生医学重点实验室,昆明 650500
2 云南省心血管疾病重点实验室,昆明医科大学附属延安医院心内科,昆明 650051
通讯: 戴海龙 Email: 46944404@qq.com
DOI: 10.3978/j.issn.2095-6959.2021.03.027
基金: 云南省教育厅科学研究基金(2015J055)。

摘要

成年哺乳动物大脑仍然能够产生新生神经元的发现点燃了一个新的研究领域——神经发生。目前认为研究成年后的神经发生对进一步了解大脑功能和衰老,脑肿瘤、神经系统退行性疾病的发病机制和治疗,中枢神经系统的损伤修复等均具有重要的意义。成体神经发生是一个复杂的多步骤过程,每个阶段都受细胞内在基因表达程序和细胞外微环境因素的精细调控。越来越多的证据表明miRNAs代表了一类转录后基因表达调控因子,是控制成体神经发生的基因调控网络的重要组成部分。
关键词: miRNA;成体神经发生;啮齿类动物;基因调控

Role of miRNAs in adult neurogenesis

Authors: 1ZHU Hongmei, 1ZHANG Fenglan, 2DAI Hailong
1 Key laboratory of Stem Cell and Regenerative Medicine of Yunnan Province, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming 650500, China
2 Key Laboratory of Cardiovascular Disease of Yunnan Province, Department of Cardiology, Yan’an Affiliated Hospital of Kunming Medical University, Kunming 650051, China

CorrespondingAuthor: DAI Hailong Email: 46944404@qq.com

Foundation: This work was supported by Scientific Research Fund Project of Yunnan Provincial Department of Education, China (2015J055).

Abstract

The finding that the adult mammalian brain is still capable of producing neurons has ignited a new field of research, namely neurogenesis. It is currently considered that the study of adult neurogenesis may contribute to further understanding of how to maintain the normal brain function and aging, pathogenesis and treatment of brain tumors, neurodegenerative diseases, as well as damage and repair of the central nervous system. In addition, adult neurogenesis is a complex multi-step process, each of which is finely regulated by cell-intrinsic gene expression and extra cellular microenvironmental factors. Accumulating evidence suggests miRNAs, which represent a class of post-transcriptional gene expression regulators, are a crucial part of the gene regulatory networks governing adult neurogenesis.
Keywords: miRNAs; adult neurogenesis; rodent; genetic regulation