化疗药物致心脏毒性的机制及防治进展
| 作者: |
1王素丽,
1詹成创,
1苏梦琦,
1薛红杰
1 哈尔滨医科大学附属第一医院心内科，哈尔滨 150001 |
| 通讯: |
薛红杰
Email: 473003446@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.01.032 |
| 基金: | 黑龙江省教育厅的资助项目(12541306)。 |
摘要
近年来随着诊疗水平提高，肿瘤患者生存期已获得延长，但非肿瘤相关健康问题日益突显。其中，化疗药物所致的心血管疾病，如心功能不全、心房颤动、室性早搏、高血压、急性冠脉综合征、血栓栓塞事件、心包炎等并发症日益突出。严重心血管并发症已成为影响肿瘤患者预后的重要因素，而全面了解化疗药物心脏毒性、有针对性地防治以减轻化疗所致的心脏损伤，已成为影响化疗是否成功的重要因素。
关键词：
化疗药物；心脏毒性；机制；防治
Mechanism, prevention and treatment in cardiac toxicity caused by chemotherapy drugs
CorrespondingAuthor: XUE Hongjie Email: 473003446@qq.com
DOI: 10.3978/j.issn.2095-6959.2021.01.032
Foundation: This work was supported by the Foundation Project of Education Department of Heilongjiang Province, China (12541306).
Abstract
In recent years, with the improvement of diagnosis and treatment in cancer, the survival period of patient with cancer is getting more optimistic, while non-cancer related health problems are becoming more and more prominent. The cardiovascular diseases caused by chemotherapy are the most critical problem awfully impacting the patients’ life, such as the cardiac dysfunction, atrial fibrillation, premature ventricular contraction, hypertension, acute coronary syndrome, thromboembolic disease, pericarditis complications are increasingly prominent. However, comprehensive understanding of the cardiotoxicity of chemotherapy drugs, targeted prevention and treatment to reduce the heart damage caused by chemotherapy have become important factors affecting the success of chemotherapy.
Keywords：
chemotherapy drugs; cardiac toxicity; mechanism; prevention and treatment