Gestational trophoblastic neoplasia (GTN) is a group of tumors closely associated with pregnancy. The malignant forms can arise after any type of pregnancy, mainly after hydatidiform mole, the rest can occur after a spontaneous abortion, a term, ectopic pregnancy or a premature birth. The metastasis of GTN appears early with many sites involved, which are commonly found in the lungs. Some patients with GTN in special sites (only those outside the reproductive system and lungs are discussed in this article) see their doctors only because of their symptoms related to special metastatic lesions, while there is no evidence of GTN in genitalia or lungs after imaging or histopathological examination. It may be related to the disappearance of primary lesions and development of metastatic lesions in special sites. This review aims to summarize the diagnosis, treatment protocols and prognosis of GTN in special sites.