Objective: To observe and analyze the effect of precision nursing on postoperative complications rate and nursing satisfaction of elderly patients with laparoscopic cholecystectomy. Methods: A total of 130 patients (age ≥60 years) with laparoscopic cholecystectomy in Shanghai 10th People’s Hospital from May 2016 to May 2018 were selected. They were randomly divided into a study group (n=65) and a control group (n=65). The control group was given routine nursing, and the research group added precision nursing on the basis of the control group. The incidence of complications and nursing satisfaction of the two groups were compared within 7 days after the nursing operation. Results: The postoperative complications rate in the study group was 7.7%, which was significantly lower than that in the control group (21.5%), and the difference was statistically significant (P<0.05). The satisfaction score of the study group was 96.7%, which was significantly higher than that of the control group (85%), and the difference between the two groups was statistically significant (P<0.05). Conclusion: The application of precision nursing can help reduce the incidence of complications within 7 days after laparoscopic cholecystectomy in elderly patients, which is conducive to improving nursing satisfaction scores. Precision nursing has a high promotion value.