文章摘要

2型糖尿病胰岛素抵抗与阿尔茨海默病

作者: 1王莹, 1付羽鸿, 1高昕媛
1 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150000
通讯: 高昕媛 Email: 15369337970@163.com
DOI: 10.3978/j.issn.2095-6959.2021.03.028

摘要

2型糖尿病(type 2 diabetes mellitus,T2DM)是一种复杂而异质的代谢紊乱,可导致不同程度的胰岛素抵抗和B细胞功能障碍。胰岛素抵抗与认知功能障碍之间存在明确的联系,而认知功能障的终点为阿尔茨海默病(Alzheimer’s disease,AD)。因此,AD和T2DM之间的关键交叉点可能是胰岛素抵抗。胰岛素抵抗显著影响海马可塑性,改变淀粉样蛋白前体蛋白(amyloid precursor protein,APP)代谢,增加tau蛋白浓度,并改变脑组织结构。
关键词: 2型糖尿病;阿尔茨海默症;中枢胰岛素抵抗;海马胰岛素抵抗

Insulin resistance in type 2 diabetes mellitus and Alzheimer’s disease

Authors: 1WANG Ying, 1FU Yuhong, 1GAO Xinyuan
1 Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin 150000, China

CorrespondingAuthor: GAO Xinyuan Email: 15369337970@163.com

Abstract

Type 2 diabetes mellitus (T2DM) is a complex and heterogeneous metabolic disorder that leads to varying degrees of insulin resistance and B cell dysfunction. There is a clear link between insulin resistance and cognitive impairment, which ends in Alzheimer’s disease (AD). Therefore, the key crossover point between AD and T2DM may be insulin resistance. Insulin resistance significantly affects hippocampal plasticity, changes amyloid precursor protein (APP) metabolism, increases tau protein concentration, and changes brain tissue structure.
Keywords: type 2 diabetes mellitus; Alzheimer’s disease; central insulin resistance; hippocampal insulin resistance