Objective: To investigate the clinical effect of silver ion excipients combined with gentamicin sulfate in the treatment of gynecologic tumor peripheral vein implantation central venous catheter (PICC) patients with catheterization infection and the value of prevention and control of complications. Methods: A total of 94 gynecological tumor patients who were treated with PICC in our hospital from January 2016 to December 2018 were selected as the subjects, and all patients were divided into two groups on average according to random table method, and 47 patients were observed in the observation Group and control group. The patients in the observation group were treated with silver ion excipients combined with gentamicin sulfate, and the control group patients were treated with conventional methods. The incidence of puncture point infection was compared between the two groups, the effect of infection treatment was compared between the two groups, the occurrence of puncture point seepage and phlogistic in two groups, and the incidence of adverse reactions were compared, and the distribution of pathogenic bacteria in infected patients was statistically analyzed. Results: There was no statistically significant difference in the incidence of puncture point infection between the two groups of patients P>0.05. Compared with the effect of infection treatment, it was found that the overall effective rate of patients in the observation group was 82.98% (39 cases), the overall effective rate of the control group was 61.7% (29 cases), and the patients in the observation group had effective treatment and the number of patients were higher than those in the control group, and the difference between the two groups was statistically. Compared with the occurrence of puncture point seepage and phlogistic, it was found that the incidence of puncture point seepage, the incidence of phlogistic and the incidence of adverse reactions in the observation group were lower than those in the control group, and the difference between the two groups of data was statistically significant P<0.05. The distribution of pathogenic bacteria in infected patients showed that 104 strains of pathogenic bacteria were detected, including 62 strains of Gram-negative bacteria (59.6%), 37 strains of Gram-positive bacteria (35.6%), 4 strains of fungi (3.8%) and 1 strains of other strains (1%). Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae were the main gram-negative bacteria, and gram-positive bacteria were mainly Staphylococcus aureus. Conclusion: The application of silver ion excipients combined with gentamicin sulfate in gynecologic tumor PICC implantation is beneficial to improve the therapeutic effect of infection and reduce the incidence of adverse reaction of PICC, which is helpful to ensure the quality of life of patients.