Objective: To compare and analyze the effect of different rehabilitation nursing methods in the care of patients with chronic obstructive pulmonary disease (COPD). Methods: Ninety patients with COPD treated in Huaian First People’s Hospital were randomly divided into group A, B, and C, with 30 in each group. Group A received routine rehabilitation nursing, group B received evidence-based rehabilitation nursing, and group C received systematic rehabilitation nursing. The patient’s lung function indicators [forced vital capacity (FVC) and forced expiratory volume at 1 second (FEV1)] and quality of life [Quality of Life Rating Scale (GQOL-74) evaluation] were used as the main observation indicators in this study. Results: After nursing, the FVC and FEV1 in group B and C were higher than those in group A (P<0.05), and the average physical function, mental state, material life and social function scores on the GQOL-74 scale were higher than those in group A (P<0.05), but there was no significant difference between group B and group C (P>0.05). Conclusion: Evidence-based rehabilitation nursing and systemic rehabilitation nursing can achieve good rehabilitation results in the clinical nursing of patients with COPD, which is of great significance to improve the pulmonary function and quality of life of patients.